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眼前节光学相干层析图像中央角膜厚度自动测量

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  • 1. 清华大学计算机科学与技术系,北京100084
    2. 澳门科技大学资讯科技学院,澳门特别行政区999078
孙延奎,博士,副教授,研究方向:小波分析、可视化与图形学、图像处理,E-mail: syk@mail.tsinghua.edu.cn

收稿日期: 2011-11-07

  修回日期: 2012-02-22

  网络出版日期: 2012-02-22

基金资助

国家自然科学基金(No.60971006);澳门特别行政区科学技术发展基金(No.063/2010/A)资助

Automatic Measurement of Central Cornea Thickness of Eye Anterior Segment Optical Coherence Tomography Image

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  • 1. Department of Computer Science and Technology, Tsinghua University, Beijing 100084, China
    2. Faculty of Information Technology, Macau University of Science and Technology, Macao SAR 999078, China

Received date: 2011-11-07

  Revised date: 2012-02-22

  Online published: 2012-02-22

摘要

为了自动获取所需医学参数,辅助医生诊断,提出了一种基于边缘检测和随机抽样一致性的中央角膜厚度自动测量方法. 采用边缘检测算子获得眼前节组织光学相干层析图像中的初始边缘,然后利用随机抽样一致性算法对初始中央角膜上边缘进行圆弧拟合,进一步提取中央角膜下边缘并采用相同方法进行圆弧拟合,根据得到的中央角膜上下边缘计算中央角膜厚度. 实验结果表明,该算法能排除图像中时常出现的中央亮线干扰,实时而准确地提取中央角膜上下边缘,得到的中央角膜厚度计算结果与人工分析基本一致,具有良好的应用价值和商业前景.

本文引用格式

舒鹏1, 孙延奎1, 田小林2 . 眼前节光学相干层析图像中央角膜厚度自动测量[J]. 应用科学学报, 2012 , 30(6) : 619 -623 . DOI: 10.3969/j.issn.0255-8297.2012.06.010

Abstract

 To obtain quantitative parameters automatically and help medical diagnosis, automatic measurement of central cornea thickness based on edge detection and random sample consensus (RANSAC) is employed. The initial edge in the eye anterior segment optical coherence tomography (OCT) image is obtained with an edge detector. Upper and lower edges of the central cornea are extraxted using the RANSAC circle fitting method. The central cornea thickness is then computed based on the edges. Experiments show that the proposed method can avoid the effect of light beam crossing, and good results comparable to manual analysis can be obtained in real time, indicating that the method has potential applications in the future.

参考文献

[1]HUANG D, SWANSON E A, LIN C P, SCHUMAN J S, STINSON W G, CHANG W, HEE M R, FLOTTE T, GREGORY K, PULIAFITO C A, FUJIMOTO J G. Optical coherence tomography [J]. Science, 1991, 254(5035): 1178-1181.

[2]WOLFGANG D, JAMES G F. State-of-the-art retinal optical coherence tomography [J]. Progress in Retinal and Eye Research, 2008, 27(1): 45~88

[3]MATHEW P T, DAVID S, THOMAS N. Endothelial cell loss and central corneal thickness in patients with and without diabetes after manual small incision cataract surgery [J]. Cornea, 2011,30(4): 424-428

[4]刘爱林,陈常详. 眼前节组织OCT图像角膜中央厚度测量 [J]. 中国医学物理学杂志,2009, 26(3): 1172-1175.

LIU Ailin, CHEN Changxiang. Central cornea thickness measured in the anterior chamber OCT image [J]. Chinese Journal of Medical Physics, 2009, 26(3): 1172-1175. (in Chinese)

[5]GRAGLIA F, MARI J L, SEQUEIRA J. Cornea contour extraction from OCT radial images. Advanced Knowledge Application in Pratice, Igor Fuerstner, 2010, 341-352.

[6]CORON A, SILVERMAN R H, SAIED A, LAUGIER P, Automatic segmentation of the anterior chamber in in-vivo high-frequency ultrasound images of the eye [C]// IEEE International Conference on Ultrasonics Symposium, 2007:1266 – 1269.

[7]LIN LI FAN, JU YING. Automatic extraction of the anterior chamber contour in OCT images [C]// the Second International Symposium on Information Science and Engineering, 2009: 423-426.

[8]EICHEL J A, MISHRA A K, CLAUSI D A, FIEGUTH P W, BIZHEVA K K. A novel algorithm for extraction of the layers of the cornea [C]// Canadian Conference on Computer and Robot Vision, 2009: 313-320.

[9]FISCHLER M A, BOLLES R C. Random sample consensus: a paradigm for model fitting with applications to image analysis and automated cartography [J]. Communications of the ACM, 1981, 24(6): 381-395

[10]朱毅,何永红,李鹏,何卫红,高应俊,曾楠,马辉. 光学相干层析图像层状结构的增强与定量测量 [J]. 光学学报,2007, 27(3): 515-520.

ZHU Yi, HE Yonghong, LI Peng, HE Weihong, GAO Yingjun, ZENG Nan,MA Hui. Enhancement and quantitative measurement of layer structures in optical coherence tomographic images [J]. Acta Optica Sinica, 2007, 27(3): 515-520. (in Chinese)

[11]舒鹏,孙延奎,田小林. 采用双树复小波和混合概率模型的光学相干层析图像去噪 [J]. 应用科学学报,2011,29(5): 467-472.

SHU Peng, SUN Yankui, TIAN Xiaolin. Denoising of Optical Coherence Tomography Image Using Dual-Tree Complex Wavelet Transform and Mixed Probability Model [J]. Journal Of Applied Sciences, 2011, 29(5):467-472.

[12]OSTU N. A threshold selection method from gray-level histograms [J]. IEEE Transactions on Systems, Man, and Cybernetics, 1979, 9(1): 62-66

[13]ENG H L AND MA K K. Noise adaptive soft-switching median filter for image denoising [C]// IEEE International Conference on Acoustics, Speech, and Signal Processing, 2000: 2175-2178

[14]MARTIN B, MARTIN J T, BERNHARD R, STEPHANIE U, MICHAEL W U, KLAUS L. Central corneal thickness determined with optical coherence tomography in various types of glaucoma [J]. British Journal of Ophthalmology, 2000, 84(11): 1233-1237

[15]蔡守东,何永红,李晖,李志芳,李鹏,代祥松,吴蕾. 眼前节光学相干层析系统的设计及实验研究 [J]. 光电子•激光,2010, 21(4): 628-631.

CAI Shoudong, HE Yonghong, LI Hui, LI Zhifang, LI Peng, DAI Xiangsong and WU Lei, Study of the eye anterior segment imaging system with optical coherence tomography [J]. Journal of Optoelectronics Laser, 2010, 21(4): 628-631. (in Chinese)

[16]CANNY J. A Computational approach to edge detection [J]. IEEE Transactions on Pattern Analysis and Machine Intelligence,1986, 8(6): 679-698
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