收稿日期: 2011-02-28
修回日期: 2011-06-02
网络出版日期: 2012-05-30
基金资助
国家自然科学基金(No.61075019);重庆市自然科学基金(No.2009BB2080);教育部留学回国人员科研启动基金(教外司留[No.2010]1174);重庆邮电大学科研基金(No.A2009-06)资助
Molecular Classification of Acute Leukemia Using EHW with Filter-Based Gene Selection
Received date: 2011-02-28
Revised date: 2011-06-02
Online published: 2012-05-30
王进1;3, 丁凌1, 孙开伟1, 李钟浩2 . 过滤特征基因选择及演化硬件急性白血病分型[J]. 应用科学学报, 2012 , 30(3) : 287 -293 . DOI: 10.3969/j.issn.0255-8297.2012.03.012
A virtual reconfigurable architecture-based intrinsic evolvable hardware (EHW) is proposed for the molecular classification of cancer. To efficiently process DNA microarray datasets and cooperate with the hardware realization of EHW, five different filter-based gene selection methods are compared and discussed in this paper. The EHW classification system handles the selected informative genes through two stages: system
learning and system classification. Empirical studies on a human acute leukemia dataset demonstrate that classification accuracy of the gene selection scheme based on signal-to-noise ratio outperforms its competitors. Classification accuracy of the proposed EHW is high comparable with other state-of-the-art pattern recognition methods. The system recognition time is reduced to 0.12 ms.
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