This paper proposes a cross-platform framework for hybrid simulation based on the interaction between colored Petri net (CPN) and Matlab, using Petri net as a tool for simulation process control. Utilizing and extending the concept of substitution transition, with the function of fusion place and folding, this framework can accomplish complex logical modeling and establishment of imbedded continuous process for hybrid systems. Besides, the analytical function of CPN reduces difficulty in logical verification for hybrid systems with complex logical behaviors. Finally, by modeling, simulation and analysis of a simple instance, feasibility of the platform and validity of the logic are shown. It provides a new method of modeling and simulation for large and complicated hybrid systems.