咖啡因-β-环糊精包结物的研究

应用科学学报 ›› 1993, Vol. 11 ›› Issue (1): 51-57.

咖啡因-β-环糊精包结物的研究

黄为钧, 周砚珠, 蒋曼, 李立璞, 金顺子, 谈夫

中国科学院化学研究所分子动态和稳态结构国家实验室

收稿日期:1991-02-18 修回日期:1991-07-15 出版日期:1993-03-31 发布日期:1993-03-31
基金资助:
北京中关村地区联合分析测试中心基金券资助

STUDY ON INCLUSION COMPLEX OF CAFFEINE AND β-CYCLODEXTRIN

HUANG WEIJUN, ZHOU YANZHU, JIANG MAN, LI LIPU, JIN SHUNZHI, TAN FU

Institute of Chemistry, Academia Sinica

Received:1991-02-18 Revised:1991-07-15 Online:1993-03-31 Published:1993-03-31

摘要/Abstract

摘要： 该文将咖啡因与β-环糊精形成包结物.研究了包结物的制备方法,并应用热重-差热分析、核磁共振谱和红外光谱三种方法鉴定了包结物的物性.实验结果表明,药物分子被包结在β-环糊精分子疏水性空穴内,其失重速率降低了,热稳定性提高了以及包结物中环糊精分子1位氢的δ值随咖啡因含量减少而增大.

关键词: 咖啡因, β-环糊精, 包结物, 热重-差热分析

Abstract: The inclusion complex of caffeine and β-cyclodextrin was prepared, and its properties were studied by using the thermogravimetry-differential thermal analysis, nuclear magnetic resonance and infrared spectroscopy. The experi mental results showed that the caffeine molecule was included in the hydrophobic cavity of β-cyclodextrin molecule and its thermal stability was increased.

Key words: Caffeine, β-Oyclodextrin, Inclusion complex, TG-DTA (Thermogravimetry-differential thermal analysis)

黄为钧, 周砚珠, 蒋曼, 李立璞, 金顺子, 谈夫. 咖啡因-β-环糊精包结物的研究[J]. 应用科学学报, 1993, 11(1): 51-57.

HUANG WEIJUN, ZHOU YANZHU, JIANG MAN, LI LIPU, JIN SHUNZHI, TAN FU. STUDY ON INCLUSION COMPLEX OF CAFFEINE AND β-CYCLODEXTRIN[J]. Journal of Applied Sciences, 1993, 11(1): 51-57.