Abstract: A multi-resolution elastic registration method based on edge contour is presented. The C-V（Chan-Vese） model is applied to extract source and target contours from two human brain MR images. A multi-resolution simulated annealing procedure is proposed to match the two contour point sets with low computation cost. This way, a fast elastic registration method using B-spline interpolation function is obtained. Experimental results show that the proposed method provides fast image registration without loss of precision.

Key words: C-V model, B-spline, simulated annealing, multi-resolution, elastic registration