中文

Journal of Applied Sciences ›› 2011, Vol. 29 ›› Issue (2): 133-139.doi: 10.3969/j.issn.0255-8297.2011.02.005

• Signal and Information Processing • Previous Articles     Next Articles

Detection of Weak Signals Generated by Surface Plasmon Resonance Biomedical Sensors Using Photodiode-Array Device

WANG Cheng, ZHANG Wei, ZHAO Zi-chun, LIU Guo-hua   

  1. College of Information Technical Science, Nankai University, Tianjin 300071, China
  • Received:2010-11-23 Revised:2011-02-04 Online:2011-03-23 Published:2011-03-24
  • About author:王程，博士生，研究方向：生物医学传感器、智能化仪器仪表、信息论与编码，E-mail: juvenok@mail.nankai.edu.cn；刘国华，博导，研究方向：生物医学传感器，E-mail: liugh@nankai.edu.cn
  • Supported by:

    国家自然科学基金(No.60574091, No.60871028, No.61001056)；天津市科技计划项目基金(No.06YFGPGX08700, No.08JCYBJC12500,No.09ZCKFGX01200, No.10JCZDJC15300)资助

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Abstract:

This paper proposes an efficient de-noising method using a photodiode-array device to improve detection capability of surface plasmon resonance (SPR) sensors. Using reference noise signals output from the photodiode-array, we combine the coherence de-noising technique and the wavelet de-noising using soft threshold so as to raise the output SNR from 40 dB to over 52 dB. Experiments of human immunoglobulin G (IgG) molecules specific combinations show that the proposed de-noising method can remarkably enhance resolution of SPR sensors. Using this method, the SPR sensor can quantitatively detect tiny change of IgG molecule contents in solution samples with an order of 10?3 mg/mL, showing an improvement of more than one order of magnitude in detection accuracy and resolution.

Key words: photodiode-array, surface plasmon resonance(SPR), coherence de-noising, wavelet soft threshold de-noising, specific combination of biology molecules

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