微流激光生化传感技术综述

doi:10.3969/j.issn.0255-8297.2021.05.007

Abstract

Abstract: Optofluidic laser has shown great potential in biochemical sensing. Here in this review, we systematically introduced the sensing mechanism and research progress of optofluidic laser based biochemical sensors. The gain medium regulated optofluidic laser sensing mainly depends on the quantity and state of gain molecules. When the biochemical reaction or molecules change the characteristics of microcavity, the resonance condition changes accordingly, and the change can be reflected and read out in the modes, wavelength and emission direction of lasing light. Furthermore, the biochemical molecules can introduce absorption loss and scattering loss in the laser cavity, causing measurable deterioration in laser intensity. Thanks to the amplification of lasing process and optical microcavity, and the narrow linewidth of laser, the laser output characteristics are ultrasensitive to the subtle changes of biochemical process to achieve high sensitivity and high-throughput biochemical sensing.

Key words: optofluidic laser, biochemical sensing, gain medium, optical microcavity, loss

CLC Number:

Q631

WANG Chaoqin, SONG Haoyue, YANG Xi, WANG Yanqiong, GONG Yuan. Review of Optofluidic Laser Based Biochemical Sensing[J]. Journal of Applied Sciences, 2021, 39(5): 809-820.

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Review of Optofluidic Laser Based Biochemical Sensing

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